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JOSEPH A. LUHAN, M.D.

Arch Neurol Psychiatry 1937;37(3):479-504.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Evidence has accumulated to indicate that poliomyelitis is propagated within the central nervous system along axonal channels and that the clinical manifestations of the disease are explainable on the basis of advance of the infection solely through and within the nervous system. The excellent studies of Hurst¹ and Pette, Demme and Környey² disclosed that the early spread of virus within the neuraxis after experimental intraneural inoculation follows rather narrowly a unilateral, decussating pathway. After unilateral intracerebral inoculation the early cerebral lesions are more marked ipsilaterally (Fairbrother and Hurst³), and the lesions in the spinal cord are more severe contralaterally (Pette and his associates²).

In the present study an endeavor was made to establish the nature and pattern of distribution of the histopathologic process in fully developed experimental poliomyelitis following intracerebral inoculation with a particular strain of virus and to study the evolution of the histopathologic changes . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Nervous and Mental Diseases and the Institute of Neurology, the Northwestern University Medical School.

Footnotes
Read at a meeting of the Chicago Neurological Society, April 18, 1935.