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RICHARD C. WADSWORTH, M.D.; CLEMENTINE McKEON, M.D.

Arch Neurol Psychiatry. 1941;46(2):277-296.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

REVIEW OF LITERATURE

Seven years after Paulesco¹ described the train of symptoms which followed the experimental removal of the pituitary gland in dogs, Morris Simmonds, a Hamburg physician, demonstrated the relationship of destruction of the anterior lobe of the pituitary gland to the clinical picture of pituitary cachexia which now bears his name.² Since this time over 200 cases have been reported in the literature, but only one third of these have been verified by autopsy. In 1938, Lisser and Ascarilla³ collected 69 pathologically verified cases. As a result of a detailed statistical study of these cases they suggested four cardinal characteristics on which the clinical diagnosis of Simmonds' disease should be based: viz., loss of weight, frequently progressing to emaciation; diminished sexual function, manifested by amenorrhea and loss of libido in the female and by loss of libido and potency in the male; marked asthenia, and . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Metropolitan State Hospital, Waltham, Mass., and the Department of Pathology, Tufts College Medical School, Boston.

Footnotes
Read in part at the meeting of the New England Pathological Society, Boston, on Feb. 29, 1940.