This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal

L. RAYMOND MORRISON, M.D.

Arch Neurol Psychiatry. 1947;58(4):391-416.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE ACUTE disseminated encephalomyelitis that sometimes follows vaccination against rabies¹ or smallpox,² as well as the postinfectious encephalomyelitis following exanthematous diseases, bears such an apparently close relation to multiple sclerosis, Schilder's disease (progressive subcortical encephalopathy) and other demyelinating processes in the central nervous system that it has attracted the attention of numerous investigators in recent years. But it was in 1895 that Pierre Marie³ first stressed the observation that multiple sclerosis frequently followed smallpox. The literature has been rather completely covered by Ferraro⁴ and the reader is referred to him for a bibliography dealing with phases of the problem that are beyond the scope of the present experiments.

As long ago as 1898, while studying the toxic effects of tissues of other species, during his investigations on diphtheria and on rabies, Centanni⁵ observed the untoward effects of saline suspensions of brain injected into rabbits. He . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Department of Neuropathology and the Robert W. Lovett Fund for the Study of Crippling Disease, Harvard Medical School, and the Neuropathology Laboratory, Massachusetts General Hospital.

Footnotes
Read before the Boston Society of Psychiatry and Neurology, April 17, 1947.

A part of the expense of this investigation was defrayed by the Commonwealth Fund.