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HOWARD D. McINTYRE, M.D.; HOWARD KROUSE, M.D.

Arch Neurol Psychiatry. 1949;62(6):802-808.

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There are few references in the literature to the Guillain-Barré syndrome as a complication of antirabies vaccination. The complication of polyneuritis in the Pasteur treatment of rabies is well known. In Remlinger's¹ comprehensive statistical analysis of 234 neuroparalytic accidents, polyneuritis comprised one of the three clinical forms of neurologic complications of the therapy. The clinical picture of the polyneuritis is adequately described in the various neurologic texts. Brain² emphasized the frequency of involvement of the facial nerve, while Nielsen³ rather tersely commented, "The picture of polyneuritis occurs with rather frequent facial paralysis. This... form of disease resembles somewhat the Guillain-Barré syndrome"; but he did not pursue the subject further. The only case report found in the literature concerning polyneuritis associated with albuminocytologic dissociation as a complication of antirabies vaccination was that by Marinescu and Draganesco.⁴ They described the development of the Guillain-Barré syndrome in a man . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI; IOWA CITY

From the Department of Neurology, University of Cincinnati College of Medicine, and the Cincinnati General Hospital.