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BERRY CAMPBELL, Ph.D.; R. A. GOOD, M.D., Ph.D.

Arch Neurol Psychiatry. 1950;63(2):298-310.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EPISODES of acute disseminated encephalomyelitis following infectious disease and a variety of immunization procedures have long been an enigma to pediatricians, neurologists and neuropathologists. Causative factors in these episodes may be placed in three categories, namely, virus invasion of the nerve tissue, allergic reaction to the infecting or inoculated agent and a specific autoallergic reaction to nerve tissue itself. Investigations during the past fifteen years have increased the cogency of the last hypothesis. Extensive studies with a variety of approaches have established beyond reasonable doubt that the nerve tissue, like other tissues of the body, responds violently to antigenantibody reactions.¹ Miyagawa and Ishii,² Koritschoner and Schweinburg³ and others showed that repeated injection of emulsions of normal homologous nerve tissue in experimental animals occasionally produces symptoms of disease of the central nervous system. Rivers, Sprunt and Berry⁴ found that persistence with frequent injections of homologous or heterologous . . . [Full Text PDF of this Article]

Author Affiliations
MINNEAPOLIS

From the Departments of Anatomy and Pediatrics, University of Minnesota Medical School.

Footnotes
Helen Hay Whitney Fellow in Rheumatic Fever.

This study was supported by a grant from the National Foundation for Infantile Paralysis, Inc.