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A Family Demonstrating a Variety of Phenotypic Manifestations

WILLIAM M. LANDAU, M.D.; JOSEPH J. GITT, M.D.

A.M.A. Arch Neurol Psychiatry. 1951;66(3):346-354.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SINCE Seeligmüller¹ described the clinical, and Strümpell² the pathological, characteristics of hereditary spastic paraplegia, an extensive literature on the subject has developed, and clinical reviews have appeared by Rhein,³ Paskind and Stone,⁴ and Jackson.⁵ The genetic, as well as the clinical, aspects of the disorder have been analyzed by Bell and Carmichael.⁶

Strümpell⁷ originally described two varieties of spastic paraplegia, one developing in adult life, the other in childhood and associated with mental retardation. Rhein³ separated the cases in the literature into seven groups, distinguished by arbitrary anatomicoclinical criteria. Bell and Carmichael⁶ divided these hereditary diseases into two major genetic classes, showing recessive and dominant characteristics. respectively. Each class was further subdivided into types, designated as Friedreich's ataxia (hereditary sclerosis, spinal form), spastic ataxia, and spastic paraplegia, the last designation being justified only by the absence of ataxia. These authors believed . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Department of Neuropsychiatry, Washington University School of Medicine and St. Louis City Hospital.

Footnotes
National Paraplegia Foundation Fellow in Neurology (Dr. Landau).