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HENRY W. RYDER, M.D.; FRANK F. ESPEY, M.D.; FARISS D. KIMBELL, M.D.; LIEUTENANT (jg) ERNEST J. PENKA, MC; ADOLF ROSENAUER, M.D.; BORIS PODOLSKY, Ph.D.; JOSEPH P. EVANS, M.D.

A.M.A. Arch Neurol Psychiatry. 1952;68(2):165-169.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WE HAVE previously reported that changes in cerebral blood flow may have a profound effect in the same direction on the cerebrospinal fluid pressure of rhesus monkeys.¹ The present communication deals with this relationship in man.

MATERIAL AND METHODS

The types of patients studied and the methods of continuously recording the several pressures of interest have been described.² Included in this study are patients who were sufficiently cooperative to hyperventilate and lie quietly.

OBSERVATIONS

The administration of carbon dioxide in air increases the cerebral blood flow³ and the cerebrospinal fluid pressure.⁴ Hyperventilation decreases the flow⁵ and the fluid pressure.⁴ The cerebrospinal fluid pulse pressure varies concomitantly with the irregular arterial pulses of auricular fibrillation and extrasystoles. These procedures and conditions usually cause concomitant changes in the arterial pressure in the same direction, which have been assumed by other investigators to be the causative mechanism, . . . [Full Text PDF of this Article]

Author Affiliations
U.S.N.; With the Technical Assistance of Doris Lamb, Edythe Barnes, Joan Jackson, and William Brosene CINCINNATI

From the Department of Surgery, Division of Neurosurgery, University of Cincinnati College of Medicine.

Footnotes
This investigation was financed by a grant from the Department of the Army.

Neurosurgical Fellow, assigned by the Navy Department to the University of Cincinnati (Lieut. Penka). Fellow of the Rockefeller Foundation (Dr. Rosenauer). Consultant Physicist (Dr. Podolsky). Research Engineer, Lederle Laboratories Division, American Cyanamid Company (Mr. Brosene).