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WILLIAM H. COOK, M.D.; GEORGE W. STAVRAKY, M.D., C.M.

A.M.A. Arch Neurol Psychiatry. 1952;68(6):741-754.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT IS GENERALLY accepted that experimental stimulation of the cerebellum does not result in epileptiform convulsions. Furthermore, as stated by Penfield and Erickson,¹ "there is no good clinical evidence that lesions of the cerebellum modify or produce any increased tendency to seizures."

Cannon² and Stavraky,³ with their associates, have found that lesions within the central nervous system which lead to partial isolation of definite groups of neurones render them supersensitive to various forms of stimulation, this taking place in the absence of any detectable cytological changes in the denervated neurones (Cook, Walker, and Barr⁴). In the case of convulsant agents it was shown by Stavraky^3a and by Drake and Stavraky^3d,e that, in chronic cats, after removal of one frontal lobe or after semidecerebration, intravenous injections of acetylcholine, camphor, or pentylenetetrazol U. S. P. (metrazol^®) resulted in an asymmetrical convulsion, in which tonic manifestations . . . [Full Text PDF of this Article]

Author Affiliations
LONDON, ONT., CANADA

From the Department of Physiology, University of Western Ontario Faculty of Medicine.

Footnotes
Medical Fellow of the National Research Council of Canada (Dr. Cook); Professor of Physiology (Dr. Stavraky).

With financial assistance from the National Research Council of Canada and from the National Health Grants Administration of Canada.