This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal

Study of the Antibrain Antibodies in the Blood of Multiple Sclerosis Patients by Complement Fixation Tests

NAOMI RASKIN, M.D.

A.M.A. Arch Neurol Psychiatry. 1955;73(6):645-655.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This study is based on the premise that the serum of a multiple sclerosis patient may contain antibrain antibodies and that the disease is of an allergic nature. The etiology of multiple sclerosis being unknown, it was thought desirable to explore the possibility of a specific reaction of the blood sera of multiple sclerosis patients with the antigens prepared from the multiple sclerosis brains. Specific serologic studies in multiple sclerosis have been reported by Sachs and Steiner,¹ Steiner,² Frick,* and others. Acute disseminated encephalomyelitis accompanied by production of antibrain antibodies has been induced in animals by injection of emulsions of normal homologous and heterologous brain or spinal cord tissues, with or without adjuvants. The production of these antibodies in the monkey was reported by Kopeloff and Kopeloff.⁹ Schwentker and River¹⁰ produced antibody response in the rabbits by injections of emulsions of homologous brain. Hill¹¹ . . . [Full Text PDF of this Article]

Author Affiliations
Dorchester, Mass.

From the Pathological Laboratory and the Multiple Sclerosis Clinic of the Boston State Hospital.

Footnotes
The technical part of this work was done by Dr. Galina Rakoczy.

This work was supported by the grant from the National Institute of Neurological Diseases and Blindness, U. S. Public Health Service.